Transcranial Magnetic Stimulation Measures, Pyramidal Score on Expanded Disability Status Scale and Magnetic Resonance Imaging of Corticospinal Tract in Multiple Sclerosis

Probing the cortic ospinal tract integrity by transcranial magnetic stimulation (TMS) could help to understand neurophysiological correlations of multiple sclerosis (MS) symptoms. Therefore, study objective was, first, investigate TMS measures (resting motor threshold-RMT, evoked potential (MEP) latency, and amplitude) corticospinal in people with relapsing-remitting MS (pwMS). Then, examined conformity clinical disease-related (Expanded Disability Status Scale—EDSS) resonance imaging (MRI) results (lesion count) pwMS. The e-field navigated TMS, MRI, EDSS data were collected 23 pwMS compared non-clinical samples. show that differed from samples MEP latency for upper lower extremity muscles. Also, altered (prolonged or absent response) had higher EDSS, general pyramidal, functional scores than normal finding. Furthermore, RMT intensity muscles was predictive pyramidal scores. TMS/MEP findings classified as same 70–83% cases similar MRI results, corresponding 57–65% cases. PwMS total number lesions brain cervical tract. provides preliminary on correspondence evaluation score MS.